Coat Disease Etiology: congenital vascular malformation of retina Imaging: normal size globe, hyperdense globe, unilateral, not calcified Clinical: leukocoria, slowly progressive gradual visual loss, exudative retinal detachment Radiology Cases of Coat Disease Axial CT without contrast of the orbits (above left) shows increased density in the left vitreous humor when compared to the right. Axial FLAIR MRI of the orbits (above right) shows the vitreous humor to have high signal intensity which is isointense on T1 MRI without contrast (below left) which was felt to be consistent with proteinaceous material or hemorrhage. Axial T1 with contrast (below right) shows wispy enhancement lateral to the left globe due to retinal detachment.