Graft Versus Host Disease

  • Etiology: in immune suppressed patient who is status post bone marrow transplant, functionally competent introduced T-cells attack immunocompromized host cells in skin, liver, GI tract from esophagus to rectum with small bowel always involved
  • CT:
    — Generalized small bowel + large bowel thickening due to inflammation and sloughing of mucosal membranes with mucosal enhancement + submucosal edema without perienteric stranding, halo sign of bowel, comb sign of mesenteric vasculature
    — Ascites, hepatosplenomegaly, periportal edema
    — Mucosal enhancement of gall bladder + bladder
  • Clinical: occurs up to 30 days post bone marrow transplant, symptoms include abdominal pain / nausea / vomiting / severe diarrhea, also have skin involvement

Cases of Graft Versus Host Disease