Lissencephaly Type I Classic

  • Etiology: abnormality of neuronal migration characterized by undermigration
  • Imaging: smooth brain surface due to decreased gyri + sulci, ventriculomegaly, hour glass (Figure of 8) brain on axial images, thick cortex – thin outer cortex / cell sparse zone / thick inner cortex, thin white matter, smooth gray white junction
  • Clinical: agyria = complete lissencephayly, pachygyria = incomplete lissencephaly, band heterotopia is milder form of classic lissencephaly

Cases of Lissencephaly Type I Classic