Differential diagnosis of premature brain injury

Approach to the differential diagnosis of premature brain injury:

  • Neonatal intraventricular hemorrhage grade I can develop in utero and present after birth as a resolving subependymal cyst in the germinal matrix
  • Neonatal intraventricular hemorrhage grade I-III is confined to the germinal matrix and the ventricular system and has an etiology distinct from…
  • Periventricular hemorrhage (also known rather mistakenly as neonatal intraventricular hemorrhage grade IV) which is a wet (hemorrhagic) infarct and is most commonly unilateral
  • Periventricular leukomalacia is a dry (ischemic) infarct and is most commonly bilateral