Aspergillosis

• Etiology: Aspergillus infection whose manifestation is dependent on patient’s immune status
• Allergic Bronchopulmonary Aspergillosis (ABPA)
  — Etiology: hyperimmune status – hypersensitivity reaction associated with asthma
  — Imaging: affects airways, mucoid impaction with central bronchiectasis – “gloved finger”
  — Clinical: uncommon in children
• Aspergilloma (Fungus ball / mycetoma)
  — Etiology: normal immunity
  — Imaging: affects / infects pre-existing cavity
  — Complications: pulmonary hemorrhage
• Invasive aspergillosis
  — Etiology: hypoimmune status / immunocompromised
  — Imaging: affects parenchyma – bronchocentric / angiocentric lesion, halo sign – parenchymal density surrounded by irregular ground glass density (hemorrhagic halo), air crescent sign – central necrosis detached from wall
  — Complications: disease in brain, liver, kidneys, spleen

Cases of Aspergillosis