Imaging: — Unicentric: Well defined hypervascular mass of lymphadenopathy — Multicentric: Diffuse lymphadenopathy in the body along with hepatosplenomegaly and ascites
DDX:
Complications:
Treatment: Surgical for unicentric disease
Clinical: — Usually asymptomatic — Can present with painless lymphadenopathy in young adults — 70% in thorax, 10-15% in neck, 10-15% in abdomen — Can be unicentric (local) or multicentric (disseminated)
Radiology Cases of Castleman Disease
CXR AP (above) shows massive bilateral hilar and mediastinal lymphadenopathy. Axial CT with oral contrast and without IV contrast of the chest and abdomen (below) better demonstrates the bilateral hilar and mediastinal lymphadenopathy (lower left) and shows bilateral retroperitoneal adenopathy anterior to the psoas muscles (lower right).
