Castleman Disease

  • Etiology: unknown, benign B-cell lymphoproliferative condition
  • Imaging: lymphadenopathy
  • Treatment: surgical for unicentric disease
  • Clinical: 70% in thorax / 10-15% in neck / 10-15% in abdomen, can be unicentric or multicentric, usually asymptomatic, can present with painless lymphadenopathy

Cases of Castleman Disease

CXR and CT of Castleman disease
CXR AP (above) shows massive bilateral hilar and mediastinal lymphadenopathy. Axial CT with oral contrast and without IV contrast of the chest and abdomen (below) better demonstrates the bilateral hilar and mediastinal lymphadenopathy (lower left) and shows bilateral retroperitoneal adenopathy anterior to the psoas muscles (lower right).