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Caudal Regression Syndrome
Etiology: anomalous differentiation of caudal cell mass — Caudal cell mass: anlage for distal spinal cord, lumbosacral bony spine, distal GI/GU tracts, thus often associated with lumbosacral hypoplasia (caudal regression), anal atresia/cloaca anomaly, GU anomalies
Imaging: — Type I – anomalous differentiation of caudal cell mass, sacral hypoplasia, abrupt wedge shaped cord termination — Type II – sacral dysplasia + tethered cord, +/- syrinx
Clinical: infant of diabetic mother, flat buttock characteristic appearance of sacral hypoplasia, Currarino’s triad consists of sacral hypoplasia or agenesis / anorectal malformation / presacral mass such as a teratoma or enteric cyst