Caudal Regression Syndrome

  • Etiology: anomalous differentiation of caudal cell mass
    — Caudal cell mass: anlage for distal spinal cord, lumbosacral bony spine, distal GI/GU tracts, thus often associated with lumbosacral hypoplasia (caudal regression), anal atresia/cloaca anomaly, GU anomalies
  • Imaging:
    — Type I – anomalous differentiation of caudal cell mass, sacral hypoplasia, abrupt wedge shaped cord termination
    — Type II – sacral dysplasia + tethered cord, +/- syrinx
  • Clinical: infant of diabetic mother, flat buttock characteristic appearance of sacral hypoplasia, Currarino’s triad consists of sacral hypoplasia or agenesis / anorectal malformation / presacral mass such as a teratoma or enteric cyst

Radiology Cases of Caudal Regression Syndrome