- Etiology: neural tube defect with anomalous differentiation of caudal cell mass with resultant abnormal development of caudal vertebral column and spinal cord
— Caudal cell mass: anlage for distal spinal cord, lumbosacral bony spine, distal GI/GU tracts, thus often associated with lumbosacral hypoplasia (caudal regression), anal atresia/cloaca anomaly, GU anomalies - Imaging:
— Type I – anomalous differentiation of caudal cell mass, sacral hypoplasia, abrupt wedge shaped cord termination
— Type II – sacral dysplasia + tethered cord, +/- syrinx - Clinical: infant of diabetic mother, flat buttock characteristic appearance of sacral hypoplasia, Currarino triad consists of anorectal malformation – anal stenosis / imperforate anus, sacral malformation – hypoplasia or agenesis or sickle shaped sacrum, presacral mass – sacrococcygeal teratoma / myelomeningocele / lipomyelomeningocele / rectal duplication
Radiology Cases of Caudal Regression Syndrome
