Pediatric Chronic Granulomatous Disease

  • Etiology: Immune deficiency disorder due to inability to destroy phagocytosed catalase-positive bacteria due to lack of NADPH oxidase resulting in formation of granulomas in different tissues
  • Imaging:
    — Recurrent pulmonary infection
    — Liver abscess
    — Inflammatory bowel disease that mimics Crohn disease
    — Recurrent osteomyelitis
  • DDX:
  • Complications:
  • Treatment:
  • Clinical: Recurrent bacterial and fungal infections of lung, liver, bones

Radiology Cases of Chronic Granulomatous Disease

CXR of chronic granulomatous disease
Initial CXR AP (above) shows an opacity in the medial aspect of the right lower lobe which took a year to resolve radiographically. CXR AP obtained 2 years after the initial CXR (below left) shows a dense opacity in the medial aspect of the right upper lobe which was only slightly reduced in size on a CXR obtained a year later (below right).

Radiology Cases of Recurrent Pulmonary Fungal Infection Due To Chronic Granulomatous Disease

CXR and CT of recurrent pulmonary fungal infection in chronic granulomatous disease
CXR AP and lateral (above) shows massive bilateral hilar lymphadenopathy and bilateral multiple small lung nodules. Axial CT with contrast of the chest in soft tissue (below left) and lung (below right) windows shows the lymphadenopathy and lung nodules to contain punctate calcifications.