- Etiology: malignant bone forming tumor
- Imaging:
— Location: most often near metaphyses of long bones (distal femur (75%), proximal tibia, proximal humerus) and extends into epiphysis in 80%
— Lytic or blastic: lytic
— Matrix: osteoid, chondroid, fibrous
— Zone of transition: (wide, narrow)
— Periosteal new bone or cortical destruction: extensive periosteal reaction (sunburst, Codman’s triangle) and permeative / moth eaten cortical destruction
— Additionally: extensive extraosseous soft tissue mass
— Radiograph: lytic and sclerotic, sunburst / spiculated periosteal reaction, cortical destruction, soft tissue mass with osteoid, Codman triangle
— MRI: non-mineralized osteoid is T1WI iso/hypointense and T2WI hyperintense, osteoid is dark on all sequences, viable tumor enhances, make sure to assess the neurovascular bundle, look for skip metastases in bones - Complications: 10-20% metastatic to lung, bone, skip metastasis to bone
- Clinical: most common malignant primary tumor of children + young adults, peak age is 13-16 years old, 80% of osteosarcoma
Radiology Cases of Conventional Osteosarcoma


Gross Pathology Cases of Conventional Osteosarcoma
