Pediatric Cytomegalovirus Encephalitis

  • Etiology: transplacental infection of CMV
  • Imaging:
    — If infection is early – before 18 weeks – see migration anomaly (lissencephaly), polymicrogyria, cerebellar hypoplasia
    — If infection is late – see destructive lesions, germinolysis, myelination delay
    — Large ventricles due to encephalomalacia, periventricular calcifications + lenticulostriate calcifications, intraparenchymal hemorrhage, microcephaly
  • Clinical: pneumonia, hepatosplenomegaly, blueberry muffin lesions on skin = petechia, purpura, mounded lesions of extramedullary hematopoesis

Radiology Cases of Cytomegalovirus Encephalitis