Cytomegalovirus Encephalitis

• Etiology: transplacental infection of CMV
• Imaging:
  — If infection is early – before 18 weeks – see migration anomaly (lissencephaly), polymicrogyria, cerebellar hypoplasia
  — If infection is late – see destructive lesions, germinolysis, myelination delay
  — Large ventricles due to encephalomalacia, periventricular calcifications + lenticulostriate calcifications, intraparenchymal hemorrhage, microcephaly
• Clinical: pneumonia, hepatosplenomegaly, blueberry muffin lesions on skin = petechia, purpura, mounded lesions of extramedullary hematopoesis

Cases of Cytomegalovirus Encephalitis