Pediatric Ovarian Granulosa Tumor

• Etiology: Malignant sex cord-stromal tumor that is an estrogen secreting functional tumor
• Imaging US:
  — Solid-cystic sponge-like ovarian mass – solid mass with variable cystic foci or predominantly cystic with small solid foci
  — Enlarged uterus with endometrial hyperplasia or polyps or carcinomas
• DDX:
• Complications:
• Treatment: Surgical
• Clinical:
  — Presentation is precocious puberty due to estradiol secretion in 82%, menorrhagia or amenorrhea, virilization in 6%
  — Most common hormonally active tumor
  — Seen in first two decades of life – 44% from 0-10 years and 34% from 11-20 years
  — 10% of all precocious puberty cases
  — Associated with Ollier Disease and Maffuci Syndrome

Radiology Cases of Ovarian Granulosa Tumor