Langerhans Cell Histiocytosis of Pituitary

Etiology: uncontrolled monoclonal proliferation of Langerhans cells
Imaging: enhancing thick hypothalamus and infundibulum
Clinical: involvement of hypothalamus leads to diabetes insipidus

Radiology Cases of Langerhans Cell Histiocytosis of Pituitary

MRI of Langerhans cell histiocytosis of the pituitary — Sagittal T1 MRI without contrast (above left) of the brain shows absence of the posterior pituitary bright spot. Sagittal (above right) and coronal T1 with contrast (above right) show a thick and enhancing pituitary stalk. Axial T1 with contrast (below right) again shows the thick enhancing pituitary stalk and enhancing lesions in both sphenoid wings and in the left orbit.