Langerhans Cell Histiocytosis of Pituitary

  • Etiology: uncontrolled monoclonal proliferation of Langerhans cells
  • Imaging: enhancing thick hypothalamus and infundibulum
  • Clinical: involvement of hypothalamus leads to diabetes insipidus

Radiology Cases of Langerhans Cell Histiocytosis of Pituitary

MRI of Langerhans cell histiocytosis of the pituitary
Sagittal T1 MRI without contrast (above left) of the brain shows absence of the posterior pituitary bright spot. Sagittal (above right) and coronal T1 with contrast (above right) show a thick and enhancing pituitary stalk. Axial T1 with contrast (below right) again shows the thick enhancing pituitary stalk and enhancing lesions in both sphenoid wings and in the left orbit.