A Pediatric Radiology textbook and Pediatric Radiology digital library
Etiology: hematological neoplasm caused by overproduction of immature (blasts) or abnormally differentiated cells of hematopoietic system in bone marrow that often extends into peripheral blood.
Imaging gastrointestinal: — Hepatosplenomegaly due to diffuse infiltration of liver and spleen by leukemic cells
Imaging spine: — Radiograph: diffuse osteopenia, loss of vertebral body height (vertebra plana) — MRI: diffuse T1 hypointense / T2 hyperintense signal with contrast enhancement (vertebral body marrow should be brighter than the disc on T1), adjacent soft tissue / leptomeningeal disease
Clinical: hepatosplenomegaly common at presentation of acute lymphoblastic leukemia