- Etiology: hematological neoplasm caused by overproduction of immature (blasts) or abnormally differentiated cells of hematopoietic system in bone marrow that often extends into peripheral blood
- Imaging chest:
— Mediastinal mass - Imaging gastrointestinal:
— Hepatosplenomegaly due to diffuse infiltration of liver and spleen by leukemic cells - Imaging musculoskeletal:
— Radiograph: 25% of bone lesions visible via radiograph, normal, osteoporosis, metaphyseal lucencies +/- fractures, permeative lesions, aggressive cortical loss, aggressive periosteal reaction, extensive marrow replacement - Imaging spine:
— Radiograph: diffuse osteopenia, loss of vertebral body height (vertebra plana)
— MRI: diffuse T1 hypointense / T2 hyperintense signal with contrast enhancement (vertebral body marrow should be brighter than the disc on T1), adjacent soft tissue / leptomeningeal disease - DDX: metastatic neuroblastoma, Langerhans cell histiocytosis, osteomyelitis, Ewing sarcoma, lymphoma
- Clinical: abnormal complete blood count, hepatosplenomegaly common at presentation of acute lymphocytic leukemia, most common pediatric malignancy
Radiology Cases of Leukemia


Radiology Cases of Splenic Involvement in Leukemia

Radiology Cases of Chloroma in Leukemia

Radiology Cases of Bone Involvement in Leukemia


Radiology Cases of Typhlitis in Leukemia
