Lhermitte-Duclos Disease

  • Etiology: Neoplasm
  • Imaging MRI:
    — T1WI: Hypointense widening of cerebellar folia giving it a striated or tigroid or corduroy or laminated appearance
    — T1WI post contrast: Minimal enhancement
    — T2WI: Hyperintense cerebellar folia
  • DDX: Cerebellitis, cerebellar infarction
  • Complications:
  • Treatment: Surgical
  • Clinical: When large may present with obstructive hydrocephalus or cerebellar dysfunction

Radiology Cases of Lhermitte-Duclos Disease

MRI of Lhermitte-Duclos disease
Sagittal (above left), axial (above right) and coronal (below left) T1 MRI without contrast of the brain shows a round lesion centered in the vermis of the cerebellum that is displacing the fourth ventricle to the left. The lesion has hypointense thickened cerebellar folia giving it a striated appearance. The cerebellar folia are hyperintense on the axial T2 MRI (below). The lesion did not enhance.