Pediatric Menetrier Disease

  • Etiology: Juvenile form linked to cytomegalovirus infection which results in gastric mucosal hypertrophy
  • Imaging UpperGI: Markedly enlarged gastric folds and rugae in fundus and body of stomach especially along greater curvature with sparing of antrum
    — Imaging Small bowel follow through: Barium is diluted due to mucosal hypersecretion resulting in impaired mucosal coating
  • Imaging CT: Thickened gastric rugae projecting into gastric lumen may resemble convolutions of brain
  • DDX: Diffuse rugal thickening can be due to gastric lymphoma, gastritis, Zollinger Ellison syndrome
  • Complications:
  • Treatment: Usually resolves spontaneously
  • Clinical:
    — Juvenile form usually occurs in children less than 10 years old
    — Present with achlorydria and hypoproteinemia (causing ascites and pleural effusions) and edema

Radiology Cases of Menetrier Disease

Upper GI and small bowel follow through of Menetrier disease
AP image from an upper GI and small bowel follow through exam shows markedly enlarged gastric folds in the fundus and body of stomach especially along greater curvature, with sparing of the antrum. The barium is slightly diluted in the jejunum and ileum.