- Etiology: heterogeneous mixture of Schwann cells / perineural cells / fibroblasts
- Imaging: often involves nerve segments next to vertebral column, nodular tumor, multiple lesions along major nerves, individual nodules may break through outer nerve sheath and extend into surrounding soft tissues, often causes sphenoid wing erosion (dysplasia)
- MRI: T2 hyperintense with +/- hypointense central focus (target sign), avid enhancement
- Clinical: development begins early in childhood, almost exclusively seen in neurofibromatosis type 1 so is pathognomonic for neurofibromatosis type 1
Radiology Cases of Plexiform Neurofibroma



Clinical Cases of Plexiform Neurofibroma
