Polyostotic Fibrous Dysplasia

  • Etiology: focal arrest in normal osteoblastic activity secondary resulting in presence of all components of normal bone with lack of normal differentiation into their mature structures
  • Imaging: multifocal, unilateral, lucent / ground glass lesion in marrow with sclerotic rim
  • Clinical: 20% of fibrous dysplasia is polyostotic, McCune-Albright syndrome (2% of fibrous dysplasia) = polyostotic fibrous dysplasia, precocious puberty, cafe au-lait spots

Cases of Polyostotic Fibrous Dysplasia