Prostaglandin E Induced Gastritis

  • Etiology: prostaglandin E – keeps patent ductus arteriosus open in patent ductus arteriosus dependent congenital heart diseases (pulmonary atresia, hypoplastic left heart syndrome) and can cause gastric mucosal hypertrophy leading to gastric outlet obstruction
  • UGI: narrowing of the pyloric channel
  • US: thickening of the echogenic central gastric mucosa with normal diameter of the pyloric muscle outside of it
  • DDX: hypertrophic pyloric stenosis

Radiology Cases of Prostaglandin E Induced Gastritis

UGI and US of prostaglandin E induced gastritis
Two lateral images from an upper GI (above) show persistent narrowing of the pylorus causing relative gastric outlet obstruction. Sagittal (left below) and transverse (right below) US of the pylorus shows the central echogenic gastric mucosa to be thickened and the pyloric muscle outside of it to be normal in diameter. The patient was also noted to be malrotated.
Upper GI and US of Prostaglandin E induced gastritis
AP image from an upper GI exam (above) shows persistent narrowing of the pyloric channel. Transverse US of the pylorus (below) shows marked thickening of the central hyperechoic pyloric mucosa and a normal thin appearance of the peripheral hypoechoic pyloric muscle which measures 1.2 mm thick.