- Etiology: Treponema pallidum causing symmetrical involvement of enchondral ossification sites
- Imaging: periosteal reaction of long bones is bilateral / symmetrical / diffuse, metaphyseal lucency / notch on proximal medial tibial metaphysis due to destruction (Wimberger’s corner sign), metaphyseal zone of provisional calcification mineralization
- Clinical: 66% present at 1-2 months and 100% present by 3 months, see hepatomegaly / splenomegaly, petechiae, jaundice, hemolytic anemia, thrombocytopenia, chorioretinitis, rhinitis, lymphadenopathy, vesiculobullous or maculopapular rash
Radiology Cases of Syphilis
