A Pediatric Radiology Textbook and Pediatric Radiology Digital Library
Wilson Mikity Syndrome
Etiology: Prematurity resulting in surfactant deficiency
Imaging: Early development of chronic lung disease including interstitial fibrosis and scarring with cystic interstitial changes
DDX:
Complications:
Treatment:
Clinical: Once felt to represent a clinically distinctive disease but now felt to be in the spectrum of bronchopulmonary dysplasia
Radiology Cases of Wilson Mikity Syndrome
CXR AP at 1 day of life (above) shows bilateral symmetrical ground glass opacities throughout the lungs which have low lung volumes. CXR AP obtained at 30 days of life (middle) shows prominent bilateral interstitial fibrosis with cystic interstitial changes throughout the lungs which have increased lung volumes. CXR AP obtained at 90 days of life (below) shows faint bilateral interstitial fibrosis with cystic interstitial changes throughout the lungs which have even more increased lung volumes.
Gross Pathology Cases of Wilson Mikity Syndrome
Post-mortem gross pathological image of both lungs (above) shows the lungs to have an irregular surface due to the presence of multiple cysts in the lungs. Magnified image (below) better shows the heterogenous nature of the cysts in the lung.
