Infant on Prostaglandin-E for ductus-dependent complex congenital heart disease Pediatric Imaging Musculoskeletal December 31, 2021October 28, 2021 AP (left) and lateral (right) radiographs of the lower extremity shows thick, dense periosteal reaction along the femur, tibia, and fibula. The diagnosis was prostaglandin osteopathy. Related Published December 31, 2021October 28, 2021