Former 31 week premature newborn now 3 days old with apnea and bradycardia

US, CT and MRI of Herpes simplex virus-2 encephalitis
Coronal US of the brain (above left) shows increased periventricular echogenicity around the anterior horns of the lateral ventricles with cystic change on the right. Axial CT without contrast of the brain (above right) shows diffuse low density throughout the brain with loss of gray matter white matter differentiation and high density hemorrhage in the posterior horn of the left lateral ventricle and in the right basal ganglia. Coronal (below right) and axial (below left) T2 MRI of the brain show diffuse necrosis developing in the brain, particularly in the frontal lobes. Intraventricular hemorrhage is again noted and the brain appears to be too smooth in appearance for the gestational age.

The diagnosis was Herpes simplex virus-2 encephalitis.