DDX of gastrointestinal polyps

Approach to the DDX of gastrointestinal polyps:

  • When a gastrointestinal polyp is discovered, consideration should be given to an underlying polyposis syndrome
    Adenomatous polyps
    — Familial polyposis syndrome
    — Turcot syndrome (associated with glioblastoma)
    Hamartomatous polyps
    — Basal cell nevus syndrome (associated with medulloblastoma)
    — Cowden syndrome
    — Cronkhite-Canada syndrome
    — Peutz-Jeghers syndrome
  • Juvenile polyps are usually found in isolation
  • Pseudopolyps may be seen in the end stage of ulcerative colitis and are actually normal mucosa surrounded by denuded ulcerated mucosa