Young adult with sickle cell disease and a headache Pediatric Imaging Neurological January 5, 2025January 9, 2025 Axial (above left), coronal (above right) and sagittal (below) CT without contrast of the skull shows diffuse massive thickening of the diploic space of the skull. The diagnosis was calvarial thickening due to marrow hyperplasia in a patient with sickle cell disease. Related Published January 5, 2025January 9, 2025