Differential diagnosis of malformations of cortical migration

• Heterotopia
• Lissencephaly Type I and Lissencephaly Type II
• Diffuse Polymicrogyria and Bilateral Perisylvian Polymicrogyria
• Schizencephaly

Approach to the differential diagnosis of malformations of cortical migration:

• Heterotopia – abnormal placement of gray matter between the ventricular system and brain cortex
• Lissencephaly – diffusely decreased gyration and sulcation of the brain leaving it with a diffusely smoother than normal appearance
• Polymicrogyria – focal areas of small haphazard appearing gyri with too few sulci
• Schizencephaly – gray matter cleft extending from the cortex to the ventricle