- Bone metastases including leukemia and lymphoma (Hodgkin, Non-Hodgkin)
- Chondrosarcoma
- Ewing sarcoma
- Fibrosarcoma
- Langerhans cell histiocytosis
- Osteosarcoma – conventional, surface (parosteal and periosteal), telangiectatic
- Synovial sarcoma
Approach to the differential diagnosis of malignant bone tumors:
- Location (diaphysis, metaphysis, epiphysis, abut articular surface)
- Lytic or blastic
- Matrix (chondroid, osteoid, fibrous)
- Zone of transition (wide, narrow)
- Periosteal new bone and / or cortical destruction
In general, malignant bone tumors tend to have a wide zone of transition with periosteal new bone formation or cortical destruction
Pediatric Imaging 