Fetus with a genetic disorder

Radiographs of chondrodysplasia punctata
CXR AP (left), lateral radiograph of the spine (center) and AP radiograph of the right lower extremity (right) obtained post mortem show asymmetric punctate calcific deposits in the epiphyses (stippled epiphyses) and around the periarticular soft tissues of the vertebral column, tarsal bones and pelvis. Platyspondyly is also seen throughout the spine. There is shortening of the proximal long bones.

The diagnosis was chondrodysplasia punctata.

Teenager with acute lymphocytic leukemia on steroids with knee pain

Radiograph and MRI of avascular necrosis of the knee
AP (above left) and lateral (above right) radiographs of the knee shows a serpiginous sclerotic lesion in the distal femur. Coronal T1 MRI without contrast of the knee (below left) shows the lesion in the distal femur to be defined by a focal serpentine low signal line with fatty center (reactive interface line) while coronal T2 MRI (below right) shows the lesion in the distal femur to be defined by a serpentine outer dark line and an inner bright line (double line sign).

The diagnosis was avascular necrosis of the knee.

Toddler with developmental delay who had a seizure and fell on the floor

Head CT of hypoparathyroidism and cavum septum pellucidum and cavum vergae
Axial (above) and coronal (below) CT without contrast of the brain shows multiple bilateral calcifications in the subcortical white matter. There are additional CSF spaces present between the leaflets of the septum pellucidum and anterior to the splenium of the corpus callosum.

The diagnosis was hypoparathyroidism in a patient with cavum septum pellucidum and cavum vergae.